The COVID-19 pandemic has caused enormous detrimental impacts on a global scale. Street vendors are one of the most heavily affected groups since they lack the skills and resources to overcome shocks. This study examines the economic burden facing this group during the pandemic and their coping strategies and mitigation mechanisms in response to these adverse effects. We utilized a mixed-methods approach, wherein 91 women vendors completed a survey questionnaire and 15 women vendors were interviewed. These vendors were found to experience a large reduction in business and consumption. The businesses of immigrant vendors suffered more adverse effects than those of local vendors. Also, the vendors selling in wet market areas incurred greater economic burdens than those selling near schools or recreation centers. The vendors lacked coping strategies to sustain their businesses and adopted various mitigation mechanisms to ensure essential consumption. This study highlights the need for urban social policies that can support this vulnerable group amid a pandemic. We also discuss policy implications for cities and economic development with a focus on street vendors.