The Covid-19 pandemic has affected all aspects of the socio-economic life of all countries in the world. Among the few business lines that can still survive and develop during the pandemic, e-commerce is considered to be the field with the most impressive growth rate. In Vietnam, the 4th outbreak of the pandemic in the southern region was like a push to boost e-commerce growth. However, to take advantage of this opportunity, ecommerce needs to overcome significant challenges related to cost and safety during the epidemic. In particular, last-mile logistics is considered the biggest challenge for e commerce in Vietnam today. The article presents opportunities for e-commerce in Vietnam during the pandemic. Besides, the paper also points out specific challenges for last-mile logistics in Vietnam, thereby proposing some solutions for Vietnam’s e-commerce to overcome these challenges