The aim of this study was to investigate the impact of entrepreneurial orientation (EO) on the performance of women-owned SMEs in Thanh Hoa, Vietnam. To achieve this research aim, the structured questionnaire was designed to investigate the responsiveness of the aspects of entrepreneurial orientation and business performance of enterprises. Stratified random sampling technique was applied. 345 collected survey questionnaires were valid and guaranteed to be included in the analysis. SPSS 20.0 software was used for exploratory factor analysis (EFA) and multiple regression. Research results show that proactiveness and innovation have a positive and significant impact while risk taking has a negative impact on business performance. Based on the actual situation, the study provides management implications to improve business performance of enterprises.